Currently, the vascular Parkinsonism term encompasses a heterogeneous set of clinical syndromes in which the predominant symptom is Parkinsonism (or a similar clinical picture but that it does not meet the necessary criteria: "pseudoparkinsonismo"), with brain ischemic lesions of different types shown by means of neuroimaging, without being suggestive findings of other degenerative causes of parkinsonism.
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| Vascular Parkinsonism - Vascular Parkinsonism Treatment Prognosis |
Although there is no doubt that cerebrovascular disease can play elements of Parkinsonism, the PV concept is not yet clearly defined and both its diagnosis and its clinical spectrum remain even without specifying.
EPIDEMIOLOGY
Because of clinical heterogeneity and the absence of a universally accepted diagnostic criteria, it is very difficult to determine accurately the epidemiological disease characteristics, although it is believed that cerebrovascular disease would only be responsible for a small proportion of cases of parkinsonism. Due to the aforementioned problems, the figures are very variable in a few studies to others, but would be located between 2.5 - 12% of all parkinsonisms (EP).
In an epidemiological study conducted in Spain en mayores de 65 AƱos, the vascular cause is estimated to be responsible for 2.5% of the cases (Benito-Leon et al 2003).
TREATMENT
Because of that the term PV encompasses different clinical syndromes with different mechanisms physiopathological is very difficult to make general recommendations for treatment.Treatment with levodopa has shown highly variable response figures in different studies but always very inferior to the response in patients with PD. Patients presenting a deficit presynaptic dopaminergic evidenced by SPECT and corresponding with ischemic lesions in RM, simulating the pathological mechanism of PD, could theoretically have a response to the administration of levodopa (Kalra et al 2010).
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